Product Name :
NGF Recepr Mouse Monoclonal Antibody [2G2]
Predicted band size :
Observed band size :
Synonyms:
CD271 antibody CD271 antigen antibody Gp80 LNGFR antibody Gp80-LNGFR antibody Low affinity nerve growth factor receptor antibody Low affinity neurotrophin receptor p75NTR antibody Low-affinity nerve growth factor receptor antibody Nerve growth factor receptor antibody Nerve growth factor receptor TNFR superfamily member 16 antibody NGF receptor antibody 展开
Function :
The Trk oncogene encodes a membrane-spanning protein tyrosine kinase, gp140Trk, whose expression is restricted in vivo to neurons of the sensory spinal and cranial ganglia of neural crest origin.116700-73-3 web Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia.474539-25-8 Chemscene Tyrosine phosphorylation of Trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF, suggesting that Trk A participates in the primary signal transduction mechanism of NGF. An additional component of the Trk A receptor complex, NGFR p75, binds to the neurotrophic factors with low affinity but is required for efficient signaling. NGFR p75 accelerates Trk A activation and may recruit downstream effector molecules to the liganded complex.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Amino acids 393-427 at the C-terminus of NGFR p75 of human origin.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IP, IF
Coupling :
unconjugated
Clone number:
2G2
RRID:
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
Store at +4℃
Storage buffer solution:
1.PMID:33722563 0 ml of PBS with
Subtype:
IgG1
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
75kDa
Positive control :
Hela, SK-N-NC.