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Most radiolabeled agents for infection imaging are markers in the infection/inflammatory approach and are unable to discriminate between the two situations. Examples include things like gallium-67 [1], indium-111 or technetium-99m (99mTc) labeled leucocytes [2,3], cytokines [4], and chemotactic peptides [5]. Agents with specificity for binding to bacteria would seem to be an proper selection as a possible bacteria certain imaging agent. Currently below investigation are 99mTc-infecton (antibiotic ciprofloxacin) [6] and 99mTc-ubiquicidin (UBI), an antimicrobial peptide [7]. External noninvasive imaging agents with adequate sensitivity to distinguish between infection and sterile inflammation are still urgently necessary. An desirable potential target is bacterial ribosomal RNAs which might be abundant in replicating and metabolically active bacteria [8]. The use of radiolabeled oligomers with base sequences antisense to mammalian mRNAs have already been effectively utilised to image tumors [9-11], the s.
